| Bioactivity | LDC000067 is a highly specific CDK9 inhibitor with an IC50 value of 44±10 nM in vitro. | ||||||||||||
| Invitro | The selectivity of LDC000067 for CDK9 over other CDKs exceeds that of the known inhibitors flavopiridol and DRB. LDC000067 displayed 55/125/210/ >227/ >227-fold selectivity for CDK9 versus CDK2/1/4/6/7. LDC000067 inhibits in vitro transcription in an ATP-competitive and dose-dependent manner. Gene expression profiling of cells treated with LDC000067 demonstrates a selective reduction of short-lived mRNAs, including important regulators of proliferation and apoptosis[1]. | ||||||||||||
| Name | LDC000067 | ||||||||||||
| CAS | 1073485-20-7 | ||||||||||||
| Formula | C18H18N4O3S | ||||||||||||
| Molar Mass | 370.43 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|