| Bioactivity | PQ401 is a potent inhibitor of IGF-IR signaling. PQ401 inhibits IGF-I-stimulated IGF-IR autophosphorylation with an IC50 of 12.0 μM in a series of studies in MCF-7 cells. PQ401 is effective at inhibiting IGF-I-stimulated growth of MCF-7 cells (IC50, 6 μM). PQ401 is a potential agent for breast and other IGF-I-sensitive cancers. PQ401 induces caspase-mediated apoptosis[1]. | ||||||||||||
| Invitro | PQ401 (1, 5, 10, 25, and 50 μM; 3 days) inhibits proliferation of cultured MCF-7 cells grown in serum or IGF-I in MCF-7 cells[1].Twenty-four hours of treatment with 15 μM PQ401 induces caspase-mediated apoptosis[1]. PQ401 inhibits autophosphorylation of the IGF-IR kinase domain at concentrations <100 nM, with an IC50 <1 μM. Cell Proliferation Assay[1] Cell Line: | ||||||||||||
| Name | PQ401 | ||||||||||||
| CAS | 196868-63-0 | ||||||||||||
| Formula | C18H16ClN3O2 | ||||||||||||
| Molar Mass | 341.79 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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