| Bioactivity | LC-MI-3 is an orally active and potent interleukin-1 receptor-associated kinase 4 (IRAK4) degrader, with a half-maximal degradation concentration of 47.3 nM. LC-MI-3 effectively inhibits the activation of downstream NF-κB signaling. LC-MI-3 can be used for the research of acute and chronic inflammatory skin[1]. |
| Formula | C39H36N8O8 |
| Molar Mass | 744.75 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen L, et al. Discovery of LC-MI-3: A Potent and Orally Bioavailable Degrader of Interleukin-1 Receptor-Associated Kinase 4 for the Treatment of Inflammatory Diseases. J Med Chem. 2024 May 23;67(10):8060-8076. |