| Bioactivity | LB42908 is a potent, selective and orally active farnesyltransferase inhibitor. LB42908 inhibits farnesylation of H-Ras, K-Ras with IC50 values of 0.9 nM, 2.4 nM for H-Ras, K-Ras, respectively. LB42908 shows antiproliferative activity. LB42908 shows antitumor activity[1]. |
| Target | IC50: 0.9 nM (H-Ras); 2.4 nM (K-Ras) |
| Invitro | LB42908 显示出抗增殖活性，对 HT29、HCT116、A549、EJ 和 T24 细胞的 GI50 值分别为 4.5、17.6、1.2、0.56、0.45 nM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> LB42908 相关抗体: |
| In Vivo | LB42908 (20, 40, 60 mg/kg; p.o.; twice daily for 21 days) 以剂量依赖性方式抑制肿瘤生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 226927-89-5 |
| Formula | C32H31N5O3 |
| Molar Mass | 533.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lee H, et al. A novel class of highly potent, selective, and non-peptidic inhibitor of Ras farnesyltransferase (FTase). Bioorg Med Chem Lett. 2001 Dec 3;11(23):3069-72. |