| Bioactivity | L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with Kis of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines[1]. |
| Target | Ki: 11 μM (EAAT1), 14 μM (EAAT3), 19 μM (EAAT2) |
| Name | L-threo-3-Hydroxyaspartic acid |
| CAS | 7298-99-9 |
| Formula | C4H7NO5 |
| Molar Mass | 149.10 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. HaraR, et al Production of L-threo-3-Hydroxyaspartic Acid Using Asparaginase-DeficientEscherichia coli Expressing Asparagine Hydroxylase of Streptomyces coelicolorA3(2). Appl Environ Microbiol. 2015 Jun;81(11):3648-54 [2]. Jensen AA, Bräuner-Osborne H. Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay. Biochem Pharmacol. 2004 Jun 1;67(11):2115-27. |
L-threo-3-Hydroxyaspartic acid
CAS: 7298-99-9 F: C4H7NO5 W: 149.10
L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with Kis of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, resp
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