| Bioactivity | L-CCG-I is an extended isomer of conformationally restricted glutamate analog. L-CCG-I also is a potent agonist for mGluR2 with an EC50 value of 0.3 nM. L-CCG-I can be used for the research of mGluR family[1]. |
| Invitro | L-CCG-I 对 mGluR2 具有活性，EC50 值为 0.3 nM[1]。L-CCG-I 有效刺激表达 mGluR1 的细胞中的磷脂酰肌醇水解[1]。L-CCG-I 可抑制毛喉素刺激的腺苷 3':5'-环磷酸（环AMP）在 mGluR2 表达细胞中的积累[1]。L-CCG-I 引起 mGluR4 毛喉素刺激的环 AMP 生成特征的抑制[1]。 |
| Name | L-CCG-I |
| CAS | 117857-93-9 |
| Formula | C6H9NO4 |
| Molar Mass | 159.14 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Y Hayashi, et al. Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells. Br J Pharmacol. 1992 Oct;107(2):539-43. |