| Bioactivity | L-706000 (MK 499) free base is a potent hERG channel blocker with an IC50 of 32 nM. L-706000 free base is a class III antiarrhythmic agent that can be used for the study of malignant ventricular tachyarrhythmias[1]. |
| Target | IC50: 32 nM (hERG channel) |
| CAS | 161799-18-4 |
| Formula | C25H29N3O4S |
| Molar Mass | 467.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. J S Mitcheson, et al. Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate. J Gen Physiol. 2000 Mar;115(3):229-40. [2]. S Vickers, et al. Metabolism of MK-499, a class III antiarrhythmic agent, in rats and dogs. Drug Metab Dispos. 1998 May;26(5):388-95. |
L-706000 free base
CAS: 161799-18-4 F: C25H29N3O4S W: 467.58
L-706000 (MK 499) free base is a potent hERG channel blocker with an IC50 of 32 nM. L-706000 free base is a class III an
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