| Bioactivity | Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally active agonist for KV7.2/7.3 channel (KCNQ2/3) with an EC50 of 1.03 μM. Kv7.2/Kv7.3 agonist 1 exhibits analgesic efficacy in mice chronic constriction injury (CCI) model and mice Streptozotocin (HY-13753)-induced diabetic peripheral neuropathic pain (DPNP) model, with ED50 of 12.02 and 9.63 mg/kg[1]. |
| CAS | 2315450-35-0 |
| Formula | C14H14FN3O2 |
| Molar Mass | 275.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Qian K, et al., Discovery of a novel KV7.2/7.3 channels agonist for the treatment of neuropathic pain. Eur J Med Chem. 2024 Oct 12;280:116953. |
Kv7.2/Kv7.3 agonist 1
CAS: 2315450-35-0 F: C14H14FN3O2 W: 275.28
Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally active agonist for KV7.2/7.3 channel (KCNQ2/3) with an EC50 of 1.03 μM
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.