| Bioactivity | KRAS G12D inhibitor 25 (Compound 148) is an inhibitor for KRAS G12C and HSP90α with IC50 of < 0.1 μM and 0.1-1 μM, respectively. KRAS G12D inhibitor 25 inhibits the proliferation of MIA PaCa-2 and NCI-H358 with EC50 of < 0.1 μM and 0.1-1 μM, respectively. KRAS G12D inhibitor 25 degrades ERBB2 with a DC50 of 0.1-1 μM[1]. |
| CAS | 2768099-61-0 |
| Formula | C56H62ClN11O6 |
| Molar Mass | 1020.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ying W, et al., Methods and compositions for targeting protein degradation. CN116615422A. |
KRAS G12D inhibitor 25
CAS: 2768099-61-0 F: C56H62ClN11O6 W: 1020.61
KRAS G12D inhibitor 25 (Compound 148) is an inhibitor for KRAS G12C and HSP90α with IC50 of < 0.1 μM and 0.1-1 μM, re
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