| Bioactivity | Kokusaginine is a furoquinoline alkaloids, which exhibits inhibitory efficacy for acetylcholinesterase (AChE) with an IC50 of 28.2 μM. Kokusaginine exhibits anti-proliferative and apoptotic inducing effects in MCF-7/ADR cells[1][2]. |
| Invitro | Kokusaginine (0-30 μM) 通过抑制微管蛋白聚合，抑制细胞 MCF-7、MDA-MB-231 及其多重耐药亚系 MCF-7/ADR、MDA-MB-231/ADR 的增殖，IC50 分别为 7.23，4.62，9.01 和 10.19 μM[2]。Kokusaginine (6-24 μM) 剂量依赖性的诱导细胞 MCF-7 及其多重耐药亚系 MCF-7/ADR 凋亡 (apoptosis)[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Kokusaginine 相关抗体: Apoptosis Analysis[2] Cell Line: |
| CAS | 484-08-2 |
| Formula | C14H13NO4 |
| Molar Mass | 259.26 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sichaem J, et al., Furoquinoline Alkaloids from the Leaves of Evodia lepta as Potential Cholinesterase Inhibitors and their Molecular Docking. Nat Prod Commun. 2015 Aug;10(8):1359-62. [2]. Chen H, et al., The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2490-2492. |