| Bioactivity | KOR/DOR agonist 2 is a KOR and DOR opioid receptors agonist with Ki values of 0.14 nM, and 0.93 nM, respectively. KOR/DOR agonist 2 shows significant antinociceptive effects. KOR/DOR agonist 2 penetrates the blood-brain barrier[1]. |
| Invitro | KOR/DOR agonist 2（化合物 21）与 MOR 的结合力为亚纳摩尔，Ki 值为 0.20 nM[1]。 在 [35S]-GTPγS 结合试验中，KOR/DOR agonist 2 在 KOR、MOR 和 DOR 处表现出功能活性，EC50 值分别为 0.04 nM、0.58 nM、1.28 nM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> KOR/DOR agonist 1 相关抗体: |
| In Vivo | KOR/DOR agonist 2（0.1 mg/kg；皮下注射；一次）在温水尾浸试验中产生显著的抗伤害作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C28H32N2O5 |
| Molar Mass | 476.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Celsey M St Onge, et al. Systematic Structure-Activity Relationship Study of Nalfurafine Analogues toward Development of Potentially Nonaddictive Pain Management Treatments. J Med Chem. 2024 May 30. |