| Bioactivity | KOR agonist 3 (Compound 5) is a κ opioid receptor (κOR) agonist with an EC50 of 0.88 nM. KOR agonist 3 also has a certain activation effect on μOR with an EC50 of 720 nM. KOR agonist 3 shows no agonist activity for δOR at concentrations less than 1 μM. KOR agonist 3 has a lower ability to induce the recruitment of β-Arrestin-2 than U50488 (HY-15997B)[1]. |
| Formula | C24H24N2O3 |
| Molar Mass | 388.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hennessy MR, et al. Discovery of Potent Kappa Opioid Receptor Agonists Derived from Akuammicine. J Med Chem. 2024 Dec 12;67(23):20842-20857. |