| Bioactivity | KLF10-IN-1 (#48-15) is a KLF10 inhibitor with an IC50 value of 40 μM against the KLF10 reporter gene. KLF10-IN-1 can suppress KLF10-DNA binding and transcriptional activity, block the conversion of CD4+CD25− T cells into CD4+CD25+ T regulatory cells, and downregulate the expression of KLF10 target genes. KLF10-IN-1 can be utilized as a useful mechanistic probe for studying KLF10-mediated effects and T regulatory cell biology[1]. |
| Target | IC50: Kru?ppel-like Factor 10 (KLF10). |
| CAS | 1197834-98-2 |
| Formula | C17H16O5 |
| Molar Mass | 300.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Khedkar SA, et al. Discovery of small molecule inhibitors to Krüppel-like factor 10 (KLF10): implications for modulation of T regulatory cell differentiation. J Med Chem. 2015;58(3):1466-1478. |