| Bioactivity | KL-465 is a PROTAC degrader for MAGE-A3, that degrades MAGE-A3 with a DC50 of 2 μM in HeLa cell. KL-465 inhibits viability of MAGE-A3 positive cancer cell HCT116, A375 and HeLa. (Blue: Ligand for E3 ligase (HY-151227); Black: Linker (HY-W679862); Pink: Ligand for target protein (HY-169087))[1] |
| Formula | C56H60N8O9S |
| Molar Mass | 1021.19 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li K, et al., Development of Ligands and Degraders Targeting MAGE-A3. J Am Chem Soc. 2024 Sep 11;146(36):24884-24891. |