KISS1-305_product_DataBase

Bioactivity	KISS1-305, the Metastin/Kisspeptin analog, is a prototype peptide and a chemical probe. KISS1-305 has suboptimal KISS1R agonistic activity, and resists plasma protease degradation[1].
In Vivo	KISS1-305 (4 nmol/h; s.c.) shows suppression of pituitary-gonadal functions[1].KISS1-305 causes substantial elevations of plasma LH and testosterone, followed by abrupt reductions of both hormone levels. KISS1-305 also reduced genital organ weight more profoundly than leuprolide. In mechanistic studies, chronic KISS1-305 administration only transiently induced c-Fos expression in GnRH neurons, suggesting that GnRH-neural response was attenuated over time[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	872717-97-0
Sequence	{d-Try}-{d-Ala(Py)}-Asn-Ser-Phe-{Gly(aza)}-Leu-{Arg(Me)}-Phe-NH2
Shortening	{d-Try}-{d-Ala(Py)}-NSF-{Gly(aza)}-L-{Arg(Me)}-F-NH2
Formula	C56H76N16O12
Molar Mass	1165.30
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Matsui H, et al.Chronic administration of the metastin/kisspeptin analog KISS1-305 or the investigational agent TAK-448 suppresses hypothalamic pituitary gonadal function and depletes plasma testosterone in adult male rats.Endocrinology. 2012 Nov;153(11):5297-308.

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