| Bioactivity | KH-CB19 is a potent CLK (cdc2-like kinase) inhibitor (CLK1 IC50=19.7 nM; CLK3 IC50=530 nM). KH-CB19 shows antiviral activity and inhibits influenza virus replication (IC50=13.6 μM)[1][2]. | ||||||||||||
| Invitro | KH-CB19 (10 μM; 1 h) shows CLK inhibition on SR protein phosphorylation in human microvascular endothelial cells[1].KH-CB19 (50 μM; 6 h) inhibits the disruption by CLK4 in A549 cells[2]. Western Blot Analysis[1] Cell Line: | ||||||||||||
| Name | KH-CB19 | ||||||||||||
| CAS | 1354037-26-5 | ||||||||||||
| Formula | C15H13Cl2N3O2 | ||||||||||||
| Molar Mass | 338.19 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Fedorov O, et al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011 Jan 28;18(1):67-76. [2]. Artarini A, et al. Regulation of influenza A virus mRNA splicing by CLK1. Antiviral Res. 2019 Aug;168:187-196. |
KH-CB19
CAS: 1354037-26-5 F: C15H13Cl2N3O2 W: 338.19
KH-CB19 is a potent CLK (cdc2-like kinase) inhibitor (CLK1 IC50=19.7 nM; CLK3 IC50=530 nM). KH-CB19 shows antiviral acti
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