| Bioactivity | KH-4-43 is an inhibitor of E3 CRL4. KH-4-43 inhibits E3 CRL4's core ligase complex and exhibits anticancer activity. KH-4-43 has a binding Kd to E3 ROC1-CUL4A CTD or the highly related ROC1-CUL1 CTD at 83 nM or 9.4 μM, respectively[1]. | ||||||||||||
| Name | KH-4-43 | ||||||||||||
| CAS | 2813310-07-3 | ||||||||||||
| Formula | C19H10ClF3N2O4 | ||||||||||||
| Molar Mass | 422.74 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Wu K, et al. Targeting Cullin-RING E3 Ubiquitin Ligase 4 by Small Molecule Modulators. J Cell Signal. 2021;2(3):195-205. |
KH-4-43
CAS: 2813310-07-3 F: C19H10ClF3N2O4 W: 422.74
KH-4-43 is an inhibitor of E3 CRL4. KH-4-43 inhibits E3 CRL4's core ligase complex and exhibits anticancer activity. KH-
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