| Bioactivity | KGP591 is a tubulin polymerization inhibitor (IC50 0.57 µM). KGP591 induces significant G2/M stagnation, inhibits cell migration, disrupts microtubule structure and cell morphology in MDA-MB-231 cells. KGP591 shows antitumor activity in orthotopic model of kidney cancer (RENCA)[1]. |
| Invitro | KGP591 (100 nM, 72 h) 在 MDA-MB-231 细胞中具有抑制细胞迁移和增殖的作用[1]>。KGP591 (100 nM, 30 min) 在 MDA-MB-231 细胞中有微管破坏作用[1]。KGP591 (200 nM, 48 h) 在 MDA-MB-231 细胞中有 G2/M 细胞周期停滞作用[1]。 0 --> KGP591 相关抗体: Cell Migration Assay [1] Cell Line: |
| In Vivo | KGP591 的磷酸盐前药 KGP618 (150 mg/kg, 皮下注射, 24 h) 在 RENCA-luc xenograft BALB/c 小鼠模型中具有肿瘤选择性血管破坏剂 (vascular disrupting agents, VDA) 疗效[1]。 Animal Model: |
| Name | KGP591 |
| Formula | C24H21NO5 |
| Molar Mass | 403.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Maguire CJ, et al. Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues. Medchemcomm. 2019 Jun 4;10(8):1445-1456. |