| Bioactivity | K-Ras(G12C) inhibitor 12 is a K-Ras(G12C) inhibitor, the half-maximum effective concentration (EC50) for K-Ras(G12C) inhibitor 12 in H1792 cells is 0.32 μM.IC50 value: 0.32 μM (EC50)Target: K-RasBinding of K-Ras(G12C) inhibitor 12 to K-Ras(G12C) disrupts both switch-I and switch-II, subverting the native nucleotide preference to favour GDP over GTP and impairing binding to Raf. In the absence of K-Ras(G12C) inhibitor 12, K-Ras(G12C) shows a slight preference for GTP (relative affinity 0.6). | ||||||||||||
| Name | K-Ras(G12C) inhibitor 12 | ||||||||||||
| CAS | 1469337-95-8 | ||||||||||||
| Formula | C15H17ClIN3O3 | ||||||||||||
| Molar Mass | 449.67 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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K-Ras(G12C) inhibitor 12
CAS: 1469337-95-8 F: C15H17ClIN3O3 W: 449.67
K-Ras(G12C) inhibitor 12 is a K-Ras(G12C) inhibitor, the half-maximum effective concentration (EC50) for K-Ras(G12C) inh
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