| Bioactivity | K-41 is an orally active antibiotic. K-41 can be obtained from Streptomyces hygroscopicus. K-41 has antibacterial and antiplasmodial activity[1][2]. |
| Invitro | K-41 抑制 Plasmodium falciparum 的 K1 和 FCR3 菌株，IC50 值分别为 8.5 和 31 nM[1].K-41 抑制 B. subtilis, B. anthracis, S. aureus, S. pyogenes, S. pneumonia, C. diphtheria 和 M. tuberculosis 的 MIC 值分别为 3.13, 1.56, 1.56, 0.78, 0.39, 0.78 以及 3.13 µg/mL[2]。 |
| In Vivo | K-41 (p.o.) 抑制小鼠的 P. berghei 和 P. yoelii 感染，ED50 值分别为 1.9 和 7.0 mg/kg[1]。 |
| Name | K-41 |
| CAS | 53026-37-2 |
| Formula | C48H82O18 |
| Molar Mass | 947.15 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Otoguro K, et al. In vitro and in vivo antimalarial activities of the monoglycoside polyether antibiotic, K-41 against drug resistant strains of Plasmodia. J Antibiot (Tokyo). 2002 Sep;55(9):832-4. [2]. Tsuji N, et al. Two new antibiotics, A-218 and K-41. Isolation and characterization. J Antibiot (Tokyo). 1976 Jan;29(1):10-4. |