| Bioactivity | DQn-1 is a potent antifolate with activity against Mycobacterium tuberculosis (Mtb) (MIC90=0.03 µM). DQn-1 directly inhibits DHFR enzyme activity, with IC50s of 8.7 and 7.6 nM for Mtb and human DHFR enzyme, respectively[1]. |
| Invitro | DQn-1 抑制 Mycobacterium tuberculosis，MIC90 值分别为 0.03 µM 和 1 µM[1]。 |
| In Vivo | DQn-1 (5-10 mg/kg; p.o. for 8 days) 未能检测到小鼠 Mtb 负荷有任何显着降低[1]。 |
| Name | DQn-1 |
| CAS | 57343-54-1 |
| Formula | C16H14ClN5O2 |
| Molar Mass | 343.77 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kumar A, et, al. A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis. ACS Infect Dis. 2015 Dec 11;1(12):604-14. |