| Bioactivity | K-252a, a staurosporine analog, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively[1][2]. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene[3]. | |||||||||
| Invitro | K-252a (3-100 nM, 8d) inhibits NGF-promoted neurite outgrowth[5]. Western Blot Analysis[4]. Cell Line: | |||||||||
| Name | K-252a | |||||||||
| CAS | 99533-80-9 | |||||||||
| Formula | C27H21N3O5 | |||||||||
| Molar Mass | 467.47 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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