| Bioactivity | JY-2 is a moderately selective and orally active Forkhead transcription factor forkhead box O1 (FoxO1) inhibitor that inhibits FoxO1 transcriptional activity with an IC50 of 22 μM. JY-2 shows moderate inhibition against FoxO3a and FoxO4. JY-2 shows anti-diabetic activity[1]. | ||||||||||||
| Target | 22 μM (FoxO1 transcriptional activity) | ||||||||||||
| Invitro | JY-2 (10-100 μM; 24 h) 降低棕榈酸 (PA;HY-N0830) 诱导的 HepG2 和 INS-1 细胞脂毒性[1]。 Real Time qPCR[1] Cell Line: | ||||||||||||
| In Vivo | JY-2 (50-200 mg/kg; oral; 3 times for two days or daily for 4 weeks) 在小鼠中显示抗糖尿病作用[1]。Pharmacokinetic parameters of JY-2[1] Parameters | ||||||||||||
| Name | JY-2 | ||||||||||||
| CAS | 339103-05-8 | ||||||||||||
| Formula | C13H7Cl2N3O | ||||||||||||
| Molar Mass | 292.12 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Choi HE, et al. Novel FoxO1 inhibitor, JY-2, ameliorates palmitic acid-induced lipotoxicity and gluconeogenesis in a murine model. Eur J Pharmacol. 2021 May 15;899:174011. |
JY-2
CAS: 339103-05-8 F: C13H7Cl2N3O W: 292.12
JY-2 is a moderately selective and orally active Forkhead transcription factor forkhead box O1 (FoxO1) inhibitor that in
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