JNK3 inhibitor-2

CAS: 2366264-18-6 F: C20H14N2O2 W: 314.34

JNK3 inhibitor-2 is a potent and selective JNK3 inhibitor with IC50 values of >100, >100, 0.25 µM for JNK1, JNK2, JNK3,

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Bioactivity	JNK3 inhibitor-2 is a potent and selective JNK3 inhibitor with IC50 values of >100, >100, 0.25 µM for JNK1, JNK2, JNK3, respectively. JNK3 inhibitor-2 shows DDR1 and EGFR (T790M, L858R) inhibition[1].
Invitro	JNK3 inhibitor-2 (compound J46) shows 30% and 60% inhibition to JNK2α2 at 30 μM and 100 μM, respectively[1].JNK3 inhibitor-2 shows inhibitory ability for DDR1 and EGFR (T790M, L858R) with IC50s of 0.16, 0.37 µM, respectively[1].
Name	JNK3 inhibitor-2
CAS	2366264-18-6
Formula	C20H14N2O2
Molar Mass	314.34
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Dou X, et al. Rational modification, synthesis and biological evaluation of 3,4-dihydroquinoxalin-2(1H)-one derivatives as potent and selective c-Jun N-terminal kinase 3 (JNK3) inhibitors. Eur J Med Chem. 2020 Sep 1;201:112445.

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