(E)-C-HDMAPP ammonium_product_DataBase

Bioactivity	(E)-C-HDMAPP ammonium, is a potent phosphoantigen in ammonium form as well as a pyrophosphonate form of (E)-HDMAPP. (E)-C-HDMAPP is also an effective activator of γδ-T cells, induces T-cell stimulatory responses in vitro (EC50=0.91 nM for TNF-α release)[1][2].
Invitro	(E)-C-HDMAPP (化合物 5E) (2 μM) 增加原代多克隆人 Vγ9Vδ2 T 细胞中的 TNF-α 释放水平，并具有刺激性生物活性[1]。
In Vivo	(E)-C-HDMAPP (化合物 5E) (0.02-10 mg/kg；静脉注射；15 天) 显着增加食蟹猴模型中的 γδ 细胞[1]。 Animal Model:
Name	(E)-C-HDMAPP ammonium
CAS	933030-60-5
Formula	C6H23N3O7P2
Molar Mass	311.21
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Boëdec A, et al. Synthesis and biological activity of phosphonate analogues and geometric isomers of the highly potent phosphoantigen (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate. J Med Chem. 2008 Mar 27;51(6):1747-54.

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