JNK-IN-8_product_DataBase

Bioactivity	JNK-IN-8 (JNK Inhibitor XVI) (GMP) is JNK-IN-8 (HY-13319) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. JNK-IN-8 is a potent JNK inhibitor with IC50s of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively[1].
Target	IC50: 4.7/18.7/1 nM (JNK1/2/3)
Invitro	JNK-IN-8 (GMP) (10 μM) reduces WNT3A-mediated neuronal differentiation[1].JNK-IN-8 (GMP) (2 μM, 7 days) enhances the self-renewal of human hematopoietic stem cells (HSCs) through the downregulation of C-JUN phosphorylation[1].
Name	JNK-IN-8
CAS	1410880-22-6
Formula	C29H29N7O2
Molar Mass	507.59
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Bengoa-Vergniory N, et al. A switch from canonical to noncanonical Wnt signaling mediates early differentiation of human neural stem cells. Stem Cells. 2014 Dec;32(12):3196-208. [2]. Xiao X, et al. Targeting JNK pathway promotes human hematopoietic stem cell expansion. Cell Discov. 2019 Jan 8;5:2.

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