| Bioactivity | JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition[1]. | |||||||||
| Target | GPX4; Ferroptosis | |||||||||
| Invitro | JKE-1716 (0~100 nΜ; 72 hours; LOX-IMVI cells) inhibits cell viability[1].JKE-1716 (LOX-IMVI cells) inhibits the expression of α-GPX4[1]. Cell Viability Assay[1] Cell Line: | |||||||||
| Name | JKE-1716 | |||||||||
| CAS | 2421118-05-8 | |||||||||
| Formula | C20H20Cl2N4O4 | |||||||||
| Molar Mass | 451.30 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Eaton JK, et al. Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. Nat Chem Biol. 2020;16(5):497-506. |
JKE-1716
CAS: 2421118-05-8 F: C20H20Cl2N4O4 W: 451.30
JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis sel
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