| Bioactivity | JHDM-IN-1 (Compound 1) is a Jumonji C domain-containing HDMs (JHDM) inhibitor with IC50s of 3.4, 4.3, 5.9, 10 and 43 μM against JMJD2C, JMJD2A, JMJD2E, PHF8 and JMJD3, respectively[1]. |
| Target | IC50: 3.4 μM (JMJD2C), 4.3 μM (JMJD2A), 5.9 μM (JMJD2E), 10 μM (PHF8), 22 μM (FIH), 31 μM (PHD3), 43 μM (JMJD3), 54 μM (PHD1), 83 μM (PHD2), 620 μM (LSD1) |
| Invitro | JHDM-IN-1 (Compound 1) 抑制 FIH、PHD3、PHD1、PHD2 和 LSD1 的 IC50 分别为 22、31、54、83 和 620 μM[1]。JHDM-IN-1 (0-100 μM) 处理 48 h 后对 KYSE150 细胞生长无抑制作用[1]。 |
| Name | JHDM-IN-1 |
| CAS | 1310809-17-6 |
| Formula | C27H29N3O6 |
| Molar Mass | 491.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Luo X, et al. A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases. J Am Chem Soc. 2011 Jun 22;133(24):9451-6. |
JHDM-IN-1
CAS: 1310809-17-6 F: C27H29N3O6 W: 491.54
JHDM-IN-1 (Compound 1) is a Jumonji C domain-containing HDMs (JHDM) inhibitor with IC50s of 3.4, 4.3, 5.9, 10 and 43 μM
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