| Bioactivity | JAK3/BTK-IN-6 (compound 14h) is a potent BTK and JAK3 dual inhibitor, with IC50 values of 0.6 and 0.4 nM, respectively. JAK3/BTK-IN-6 shows good metabolic stability in human liver microsome. JAK3/BTK-IN-6 can be used for hematological and immune diseases research[1]. |
| Invitro | JAK3/BTK-IN-6 (compound 14h) shows antiproliferative activities against hematopoietic cells (Raji, Romas, HEL, Jeko-1, and OCI-LY10), with IC50 values of 1.7, 0.5, 1.1, 0.5, and 1-10, respectively[1]. |
| Name | JAK3/BTK-IN-6 |
| CAS | 2243136-03-8 |
| Formula | C21H17BF3N5O3 |
| Molar Mass | 455.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ren J, et al. Design and synthesis of boron-containing diphenylpyrimidines as potent BTK and JAK3 dual inhibitors. Bioorg Med Chem. 2020 Jan 15;28(2):115236. |
JAK3/BTK-IN-6
CAS: 2243136-03-8 F: C21H17BF3N5O3 W: 455.20
JAK3/BTK-IN-6 (compound 14h) is a potent BTK and JAK3 dual inhibitor, with IC50 values of 0.6 and 0.4 nM, respectively.
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