| Bioactivity | JAK2 JH2 Tracer (Tracer 5) is a fluorescent probe for JAK2 JH2 domain, with a Kd of value 0.2 μM[1][2]. Storage: protect from light. | ||||||||||||
| Invitro | JAK2 JH2 Tracer shows a minimum tracer concentration that retains a satisfactory signal-to-noise ratio is found to be 1.5 pM[1].JAK2 JH2 Tracer shows a dissociation constants near 0.2 µM[1].JAK2 JH2 Tracer shows a high binding affinity with a Kd value of 0.2 μM for JAK2 JH2 domain by saturation experiments[1]. | ||||||||||||
| In Vivo | The possibility that mutations within the JAK2 JH2 domain may be associated with pathology, which is associated with a hyperactive kinase and a hematopoietic malignancy phenotype in flies[2].Specific mutation in the JAK2 JH2 domain is associated with several myeloproliferative diseases[2]. | ||||||||||||
| Name | JAK2 JH2 Tracer | ||||||||||||
| CAS | 2101955-00-2 | ||||||||||||
| Formula | C38H27F2N7O6S | ||||||||||||
| Molar Mass | 747.73 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Newton AS, et al. JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules. ACS Med Chem Lett. 2017 May 17;8(6):614-617. [2]. Ihle JN, Gilliland DG. Jak2: normal function and role in hematopoietic disorders. Curr Opin Genet Dev. 2007 Feb;17(1):8-14. |
JAK2 JH2 Tracer
CAS: 2101955-00-2 F: C38H27F2N7O6S W: 747.73
JAK2 JH2 Tracer (Tracer 5) is a fluorescent probe for JAK2 JH2 domain, with a Kd of value 0.2 μM. Storage: protect from
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.