| Bioactivity | JAK-IN-27 (compound 1) is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively. JAK-IN-27 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=23.7 nM)[1]. |
| Target | IC50: 3.0 nM (TYK2)、7.7 nM (JAK1)、629.6 nM (JAK3) |
| Name | JAK-IN-27 |
| CAS | 2673176-36-6 |
| Formula | C20H21F2N7O |
| Molar Mass | 413.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang P, et al. Preparation of pyrazolo[1,5-a]pyrazine derivatives and its use as JAK family kinase inhibitors. China, CN113150012 A. 2021-07-23. |
JAK-IN-27
CAS: 2673176-36-6 F: C20H21F2N7O W: 413.42
JAK-IN-27 (compound 1) is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (
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