| Bioactivity | JAB-2485 is a potent and selective Aurora kinase A (AURKA) inhibitor, with an IC50 of 0.33 nM. JAB-2485 exhibits around 1700-fold selectivity for AURKA over AURKB. JAB-2485 induces cell cycle arrest and apoptosis. JAB-2485 can be used for the research of cancer[1]. |
| Target | IC50: 0.33 nM (AURKA) |
| Name | JAB-2485 |
| CAS | 2899209-55-1 |
| Formula | C25H28ClF2N5O2 |
| Molar Mass | 503.97 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang G, et, al. Abstract 1645: JAB-2485: A potent, highly selective small-molecule Aurora kinase A inhibitor that targets cell division. Cancer Res (2023) 83 (7_Supplement): 1645. |
JAB-2485
CAS: 2899209-55-1 F: C25H28ClF2N5O2 W: 503.97
JAB-2485 is a potent and selective Aurora kinase A (AURKA) inhibitor, with an IC50 of 0.33 nM. JAB-2485 exhibits around
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