J-115814

CAS: 329716-61-2 F: C29H38ClN5O3S W: 572.16

J-115814 is a potent and selective neuropeptide Y1 antagonist with Ki values of 1.4, 1.8, 1.9, >10000, 620, 6000, >10000

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Bioactivity	J-115814 is a potent and selective neuropeptide Y1 antagonist with Ki values of 1.4, 1.8, 1.9, >10000, 620, 6000, >10000 nM for hY1, rY1, mY1, hY2, hY4, hY5, mY6, respectively. J-115814 inhibits feeding behaviors[1].
In Vivo	J-115814 (0.3, 1, 3, 10 mg/kg; i.v.) 可抑制 NPY 诱导的 SD 大鼠进食[1]。J-115814 (3, 10, 30 mg/kg; i.p.) 在小鼠中显示出厌食作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	329716-61-2
Formula	C29H38ClN5O3S
Molar Mass	572.16
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kanatani A, et al. A typical Y1 receptor regulates feeding behaviors: effects of a potent and selective Y1 antagonist, J-115814. Mol Pharmacol. 2001 Mar;59(3):501-5.