| Bioactivity | J-104129 is a selective and orally active muscarinic M3 receptor antagonist (Ki = 4.2 nM). J-104129 is effective in promoting bronchodilation[1][2]. |
| In Vivo | J-104129 (10 mg/kg ; p.o.; single) 在大鼠中表现出持续超过 10 h 的持久支气管扩张作用[1][2]。J-104129 (p.o.) 在大鼠中拮抗 ACh 诱导的支气管收缩，ED50 值为 0.58 mg/kg[1]。 Animal Model: |
| Name | J-104129 |
| CAS | 244277-89-2 |
| Formula | C24H36N2O2 |
| Molar Mass | 384.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mitsuya M, et al. J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors. Bioorg Med Chem. 1999 Nov;7(11):2555-67. [2]. Morihiro Mitsuya, et al. Discovery of a muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors among 2-[(1S,3S)-3-sulfonylaminocyclopentyl]phenylacetamide derivatives. Bioorg Med Chem. 2000, 8(4): 825-832. |