| Bioactivity | Erbstatin, a EGFR kinase inhibitor, possesses antineoplastic effect[1][2]. |
| Invitro | Erbstatin不抑制EGF与其受体的结合，但是会抑制EGFR复合物的内吞作用，而且该化合物不会抑制A431细胞中EGF刺激的磷脂酰肌醇代谢[2]。Erbstatin引起人小细胞肺癌（SCLC）细胞形态学凋亡和DNA断裂[3]。 |
| Name | Erbstatin |
| CAS | 100827-28-9 |
| Formula | C9H9NO3 |
| Molar Mass | 179.17 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shigeki Kobayashi, et al. Diastereomer-specific effects of double-stranded peptides conjugated with -L-Tyr-L-Phe- or -L-Tyr-D-Phe- residues on tyrosine phosphorylation and inhibition of src(ts)NRK, A431, MCF-7, and DU145 cell growth. Chem Pharm Bull (Tokyo). 2007 Nov;55(11):1585-92. [2]. M Toi, et al. Antineoplastic effect of erbstatin on human mammary and esophageal tumors in athymic nude mice. Eur J Cancer. 1990;26(6):722-4. [3]. S Simizu, et al. Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells. Cancer Res. 1996 Nov 1;56(21):4978-82. |