Iturin A-2

CAS: 83785-07-3 F: C48H74N12O14 W: 1043.17

Iturin A-2 is a cyclic lipopeptide discovered in B. subtilis and exhibits inhibitory activity against the plant pathogen

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Bioactivity	Iturin A-2 is a cyclic lipopeptide discovered in B. subtilis and exhibits inhibitory activity against the plant pathogenic fungus P. expansum (MIC = 8 µg/disk). Iturin A-2 is cytotoxic to MCF-7 and BT474 breast cancer cells, as well as HeLa cervical cancer cells, with IC50 values of 66.81, 95.04, and 77.5 µg/mL, respectively. In greenhouse studies, Iturin A-2 at concentrations of 100 and 300 mg/kg Iturin A-2 reduces the lesion area of southern corn leaf blight caused by B. maydis, and in field studies, concentrations of 300 and 500 mg/kg Iturin A-2 reduce the incidence of the disease. Iturin A-2 (12.5 µg/mL) inhibits cell division, but not nuclear division, in isolated fertilized starfish eggs[1][2][3][4].
CAS	83785-07-3
Sequence	Cyclo({d-Asn}-Gln-Pro-{d-Asn}-Ser-{(3R)-3-aminotetradecanoic acid}-Asn-{d-Tyr})
Shortening	Cyclo({d-Asn}-QP-{d-Asn}-S-{(3R)-3-aminotetradecanoic acid}-N-{d-Tyr})
Formula	C48H74N12O14
Molar Mass	1043.17
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Bland J M. The first synthesis of a member of the iturin family, the antifungal cyclic lipopeptide, iturin-A2[J]. The Journal of Organic Chemistry, 1996, 61(16): 5663-5664. [2]. Jiang J, et al. Production, purification and characterization of ‘Iturin A-2’a lipopeptide with antitumor activity from Chinese Sauerkraut Bacterium Bacillus velezensis T701[J]. International Journal of Peptide Research and Therapeutics, 2021, 27(3): 2135-2147. [3]. YE Y, et al. Identification of antifungal substance (Iturin A2) produced by Bacillus subtilis B47 and its effect on southern corn leaf blight[J]. Journal of Integrative Agriculture, 2012, 11(1): 90-99. [4]. Miyashiro S, et al. Isolation of iturin A-2 as an inhibitor of cytokinesis of starfish embryos[J]. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1986, 84: 381-384.