| Bioactivity | Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced inflammation in vascular smooth muscle cells (VSMCs)[1]. |
| Invitro | Indazole-Cl (0.1 μM；6 小时) 降低血管平滑肌细胞 (VSMC) 缺氧诱导的细胞内 ROS 水平[1]。Indazole-Cl (10 μM；24 小时) 抑制 VSMC 中缺氧诱导的环氧合酶 (COX)-2 转录活性[1]。Indazole-Cl (1 μM；24-72 小时) 可防止缺氧诱导的 VSMC 细胞迁移和侵袭[1]。 |
| Name | Indazole-Cl |
| CAS | 848142-62-1 |
| Formula | C13H9ClN2O2 |
| Molar Mass | 260.68 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Park C, et al. Indazole-Cl inhibits hypoxia-induced cyclooxygenase-2 expression in vascular smooth muscle cells. J Mol Endocrinol. 2019 Jul 1;63(1):27-38. |
Indazole-Cl
CAS: 848142-62-1 F: C13H9ClN2O2 W: 260.68
Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyc
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