DC-BPi-11 hydrochloride_product_DataBase

Bioactivity	DC-BPi-11 hydrochloride is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. DC-BPi-11 hydrochloride shows remarkable inhibition against leukemia cell proliferation[1].
Target	698 nM (BPTF)
Invitro	DC-BPi-11 hydrochloride (0.1 nM-1 μM; 24 h) 抑制人白血病MV-4-11细胞中的BPTF, EC50 为 120 nM[1]。DC-BPi-11 hydrochloride (0.01 μM-100 μM; 24 h) 显著抑制人白血病 MV-4-11 细胞增殖 (IC50=0.89 μM)，而且 (2.5 ~ 20 μM; 24 h) 还降低下游癌基因表达[1]。DC-BPi-11 hydrochloride (0.6-50 μM; 24 h) 剂量依赖性地降低 c-Myc 蛋白水平[1]。DC-BPi-11 hydrochloride 是安全的，对正常细胞的影响小[1]。
Name	DC-BPi-11 hydrochloride
Formula	C20H24ClN5O2S
Molar Mass	433.95
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Lu T, et al. Discovery of High-Affinity Inhibitors of the BPTF Bromodomain. J Med Chem. 2021 Aug 26;64(16):12075-12088.

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