Indapamide hemihydrate

CAS: 180004-24-4 F: C16H16ClN3O3S.1/2H2O W: 749.69

Indapamide hemihydrate is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vas

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Bioactivity	Indapamide hemihydrate is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide hemihydrate is also can reduce left ventricular hypertrophy[1][4].
Invitro	Indapamide (0.1-500 mg/L; 20min) reduces total insulin secretory response to glucose infusions in isolated perfused rat pancreas[2]. Indapamide (1-100 μM) increases osteoblast proliferation and decreased bone resorption[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Indapamide hemihydrate 相关抗体:
In Vivo	Indapamide (1 mg/kg/d; gastric gavage for 8 weeks) lowers blood pressure in spontaneously hypertensive rats (SHRs)[4]. Indapamide (10 mg/kg/d) decreases pressor response to oxotremorine, noradrenaline, and tyramine in rats[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	180004-24-4
Formula	C16H16ClN3O3S.1/2H2O
Molar Mass	749.69
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Chaffman, M, et, al. Indapamide. Drugs 28, 189–235 (1984). [2]. Furman BL, et, al. A further examination of the possible effects of indapamide on glucose tolerance and insulin secretion in the rat and mouse. J Pharm Pharmacol. 1981 Nov;33(11):735-7. [3]. Lalande A, et, al. Indapamide, a thiazide-like diuretic, decreases bone resorption in vitro. J Bone Miner Res. 2001 Feb;16(2):361-70. [4]. Ma F, et, al. Indapamide lowers blood pressure by increasing production of epoxyeicosatrienoic acids in the kidney. Mol Pharmacol. 2013 Aug;84(2):286-95.

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