| Bioactivity | Immunoproteasome activator 1 (compound A) is a selective immunoproteasome activator that increases the presentation of individual MHC-I–bound peptides by over 100-fold. Immunoproteasome activator 1 binds to the proteasome structural subunit PSMA1 and promotes the association of the proteasome activator PA28α/β (PSME1/PSME2) with immunoproteasomes[1]. |
| CAS | 901728-48-1 |
| Formula | C24H23N3O3 |
| Molar Mass | 401.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rana PS, et al. Immunoproteasome activation expands the MHC class I immunopeptidome, unmasks neoantigens and enhances T-cell antimyeloma activity. Mol Cancer Ther. 2024 Aug 30. |
Immunoproteasome activator 1
CAS: 901728-48-1 F: C24H23N3O3 W: 401.46
Immunoproteasome activator 1 (compound A) is a selective immunoproteasome activator that increases the presentation of i
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