| Bioactivity | Immuno modulator-1 (compound 22) inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 and 26 nM, respectively. Immuno modulator-1 shows hERG potassium channel blocking effect, with Inhibitory percentage of 20% at 3 μM[1]. |
| Invitro | Immuno modulator-1 (compound 22) 抑制 NCI-H929 人骨髓瘤细胞的增殖，IC50 为 0.6 nM[1]。 |
| In Vivo | Immuno modulator-1 (compound 22) (1 mg/kg (IV), 5 mg/kg (PO); once) 在雄性 Sprague-Dawley 大鼠中的口服生物利用度为30%[1]。 Animal Model: |
| Name | Immuno modulator-1 |
| CAS | 2757469-20-6 |
| Formula | C32H31FN6O4 |
| Molar Mass | 582.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen Xiangyang, et al. Heterocyclic immunomodulator. Patent, WO2022007659A1. |
Immuno modulator-1
CAS: 2757469-20-6 F: C32H31FN6O4 W: 582.62
Immuno modulator-1 (compound 22) inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC),
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