| Bioactivity | INF 195 is an NLRP3 inhibitor. INF 195 can inhibit NLRP3 driven macrophage pyroptosis and IL-1β release, with an EC50 value of 0.15 μM. INF 195 can reduce the infarct size of isolated mouse hearts at low doses, effectively preventing myocardial ischemia/reperfusion injury[1]. |
| Invitro | INF 195 (0.1–100 μM, 72 h) 可以抑制 NLRP3 驱动的巨噬细胞焦亡和 IL-1β 释放[1]。INF 195 (5-10 μM, 10 min) 在低剂量下可以减小离体小鼠心脏的梗死面积，有效预防心肌缺血/再灌注损伤[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> INF 195 相关抗体: Cell Cytotoxicity Assay[1]. Cell Line: |
| CAS | 1211379-56-4 |
| Formula | C17H22ClNO3 |
| Molar Mass | 323.81 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gastaldi S, et al. Novel NLRP3 inhibitor INF195: Low doses provide effective protection against myocardial ischemia/reperfusion injury. Vascul Pharmacol. 2024 Jun 17;156:107397. |