| Bioactivity | INCB16562 is an orally active, novel and selective inhibitor against JAK1/2 markedly selective over JAK3. INCB16562 potently inhibits interleukin-6 (IL-6)-induced phosphorylation of STAT3. Additionally, INCB16562 inhibits the proliferation and survival of myeloma cells dependent on IL-6 for growth, as well as the IL-6–induced growth of primary bone marrow-derived plasma cells. INCB16562 antagonizes the growth of myeloma xenografts in mice with antitumor activity. INCB16562 is promising for research of multiple myeloma[1]. |
| CAS | 933768-63-9 |
| Formula | C19H11Cl2N5 |
| Molar Mass | 380.23 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li J, et al. INCB16562, a JAK1/2 selective inhibitor, is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell support. Neoplasia. 2010 Jan;12(1):28-38. |
INCB16562
CAS: 933768-63-9 F: C19H11Cl2N5 W: 380.23
INCB16562 is an orally active, novel and selective inhibitor against JAK1/2 markedly selective over JAK3. INCB16562 pote
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