| Bioactivity | Chlorasquin inhibits thymidylate synthetase with an approximate Ki value of 4.9x10-6 M. Chlorasquin is also a folate antagonist, testing the Methotrexate (HY-14519) effect. Chlorasquin binds tighter to dihydrofolate reductase at alkaline pH than does Methotrexate (HY-14519), which is promising for research of antipsoriatic agents[1][2]. |
| CAS | 18921-73-8 |
| Formula | C20H19ClN6O5 |
| Molar Mass | 458.86 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chello PL, et al. Elevation of dihydrofolate reductase, thymidylate synthetase, and thymidine kinase in cultured mammalian cells after exposure to folate antagonists. Cancer Res. 1976 Jul;36(7 PT 1):2442-9. [2]. Hynes J B, et al. Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogs of folic and isofolic acids[J]. Journal of Medicinal Chemistry, 1977, 20(4): 588-591. |
Chlorasquin
CAS: 18921-73-8 F: C20H19ClN6O5 W: 458.86
Chlorasquin inhibits thymidylate synthetase with an approximate Ki value of 4.9x10-6 M. Chlorasquin is also a folate ant
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