| Bioactivity | ICeD-2 is a inducer of cell death, can induce HIV-1 infected cell kill. ICeD-2-mediated HIV-1 infected cell kill is dependent on HIV-1 protease activity. ICeD-2 potently blocks hydrolysis of Gly-Pro-AMC by dipeptidyl peptidase DPP8 and DPP9. ICeD-2 shows strong stabilization of DPP9 in PBMCs[1]. |
| Invitro | ICeD-2 有效阻断二肽基肽酶 DPP8 和 DPP9 对 Gly-Pro-AMC 的水解。ICeD-2 对这组肽酶表现出精湛的选择性，并且对 DPP4 和 DPP7 均具有 >3000 倍的选择性窗口[1]。在 WT THP-1 细胞中，ICeD-2 处理导致 GFP 阳性细胞丢失，而在没有 CARD8 (半胱天冬酶募集域家族成员 8)、CASP-1 (半胱天冬酶-1)或 GSDMD (gasdermin-D) 的情况下，ICeD-2 对 GFP 阳性细胞的数量几乎没有影响[1]。 |
| Name | ICeD-2 |
| Formula | C20H29N3O |
| Molar Mass | 327.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Moore KP, et al. A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells. ACS Chem Biol. 2022 Sep 16;17(9):2595-2604. |