| Bioactivity | IC 86621 is a potent DNA-dependent protein kinase (DNA-PK) inhibitor, with an IC50 of 120 nM. IC 86621 also acts as a selective and reversible ATP-competitive inhibitor.IC 86621 inhibits DNA-PK mediated cellular DNA double-strand break (DSB) repair (EC50=68 µM). IC 86621 increases DSB-induced antitumor activity without cytotoxic effects. IC 86621 can protects rheumatoid arthritis (RA) T cells from apoptosis[1][2]. |
| Invitro | IC 86621 exhibits high selectivity against other kinases such as PI3K, Cdk2, Src, PKA, PKC, Chk1, CK1, ATM, and FKBP12[1].IC 86621 (0-100 nM, 24 h) protects RA (rheumatoid arthritis) T cells from apoptosis[2]. Apoptosis Analysis[2] Cell Line: |
| Name | IC 86621 |
| CAS | 404009-40-1 |
| Formula | C12H15NO3 |
| Molar Mass | 221.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |