| Bioactivity | IAV-IN-2 (Compound MC-22) inhibits for Influenza A Virus (IAV) through blocking the entry of IAV into host cell via clathrin-mediated endocytosis (CME)[1]. |
| Invitro | IAV-IN-2 (0.01-10 µM) 抑制 IAV A/X-31 (H3N2) (IC50 为 4.08 µM)，A/WSN/33 (H1N1)，A/Udorn/72 (H3N2) 和 A/NYMC (H3N2)，抑制效力为 97%–100%[1]。IAV-IN-2 (1-1000 μM) 在细胞 A549 中表现出细胞毒性，CC50 为 33.9 μM[1]。IAV-IN-2 (10 μM) 会导致内体成熟缺陷，从而破坏病毒核心在内体运输过程中的逐步启动，使病毒无法脱去衣壳并释放基因组[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> IAV-IN-2 相关抗体: Cell Cytotoxicity Assay[1] Cell Line: |
| Formula | C22H25N3O5 |
| Molar Mass | 411.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Thottasseri AA, et al., Morpholinodiazenyl chalcone blocks influenza A virus capsid uncoating by perturbing the clathrin-mediated vesicular trafficking pathway. Arch Pharm (Weinheim). 2024 Mar 15:e2300670. |