| Bioactivity | EGFR/HER2-IN-12 (compound 14b) is a dual inhibitor of EGFR and HER2 with 81% and 51% inhibition at 10 μM. The toxicity of EGFR/HER2-IN-12 to cancer cells A431 and MDA-MB-361 was not significant[1]. |
| Target | ErbB2/HER2 |
| CAS | 2237230-21-4 |
| Formula | C25H17ClN4O3S |
| Molar Mass | 488.95 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Milik SN, et al. Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors. Eur J Med Chem. 2018 Jul 15;155:316-336. |
EGFR/HER2-IN-12
CAS: 2237230-21-4 F: C25H17ClN4O3S W: 488.95
EGFR/HER2-IN-12 (compound 14b) is a dual inhibitor of EGFR and HER2 with 81% and 51% inhibition at 10 μM. The toxicity
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