| Bioactivity | Human α-Defensin 6, a 32-residue cysteine-rich peptide, can inhibit bacterial invasion and contribute to the mucosal immunity. Human α-Defensin 6 forms ordered self-assembly fibrils and nanonets that surround and entangle bacteria after stochastic binding to bacterial surface proteins. Human α-Defensin 6 also inhibits C. albicans biofilm formation[1][2]. |
| Name | Human α-Defensin 6 |
| Sequence | Ala-Phe-Thr-Cys-His-Cys-Arg-Arg-Ser-Cys-Tyr-Ser-Thr-Glu-Tyr-Ser-Tyr-Gly-Thr-Cys-Thr-Val-Met-Gly-Ile-Asn-His-Arg-Phe-Cys-Cys-Leu (Disulfide bridge: Cys4-Cys31, Cys6-Cys20, Cys10-Cys30) |
| Shortening | AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL (Disulfide bridge: Cys4-Cys31, Cys6-Cys20, Cys10-Cys30) |
| Formula | C156H228N46O46S7 |
| Molar Mass | 3708.22 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chu H, et al. Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science. 2012 Jul 27;337(6093):477-81. [2]. Chairatana P, et al. Human α-Defensin 6: A Small Peptide That Self-Assembles and Protects the Host by Entangling Microbes. Acc Chem Res. 2017 Apr 18;50(4):960-967. |
Human α-Defensin 6
CAS: F: C156H228N46O46S7 W: 3708.22
Human α-Defensin 6, a 32-residue cysteine-rich peptide, can inhibit bacterial invasion and contribute to the mucosal im
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