| Bioactivity | Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others[1]. | ||||||
| Invitro | Hirudin 抑制凝血酶活性，剥夺凝血酶裂解纤维蛋白原的能力，阻止纤维蛋白的形成及内外凝血通路中纤维蛋白单体的交联聚合过程[1]。Hirudin 通过拮抗凝血酶，减少人微血管内皮细胞凋亡，抑制 p-JAK2 的表达[1]。Hirudin 抑制 VEGF-Notch 通路和人微血管内皮细胞增殖在高剂量时[1]。Hirudin (3-10 mg/mL) 可逆转 TGF-β1 引起的 HK-2 细胞异常增殖和纤维化[1]。Hirudin 剂量依赖性地抑制血管紧张素 II 诱导的心肌成纤维细胞，抑制氧化应激，调节纤维相关因子，抑制 ERK1/2 通路[1]。 | ||||||
| Name | Hirudin | ||||||
| CAS | 8001-27-2 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |